development and validation of a rapid derivative spectrophotometric method for determination of tropicamide in eye drops
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abstract
tropicamide is an antimuscarinic agent used as eye drops for refractive examinations. the aim of this study was to develop a simple and suitable analytical method for determination of tropicamide in eye drops in the presence of excipients. a zero-crossing third and fourth derivative spectrophotometric method was described for determination of tropicamide in eye drops. the measurements were carried out at wavelengths of 263.8 and 255.4 nm for third- and fourth-derivative, respectively. the method was found to be linear (r2> 0.999) in the range of 10-100 mg/ml for tropicamide in the presence of excipients. the limit of determination was 10 mg/ml for tropicamide. the method was successfully applied for determination of tropicamide in eye drops without any interference from excipients or need to prior separation before analysis.
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Journal title:
iranian journal of pharmaceutical sciencesجلد ۶، شماره ۳، صفحات ۱۷۱-۱۷۸
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